Forcium (Mithril in some versions) is unarguably the best build for PvE.
I dont think there is a best weapon for PvE as it dont really relate with defense/def-rate. So obviously the best weapon is the weapon that deals more damage. A mithril/forcium 40/7?
Accessories depends... Vampiric or Drosnin earings? Both can be HP I love you >.<♥I love you >.<♥I love you >.<♥I love you >.<♥ers (vamp), I prefer drosnin (with hp steal stats) though for the additional def rate.
Epaulet: EoS +8.