:/
Sounds like you have a mouse that has built in hardware macros most likely, like a gaming mouse, a lot of buttons and you can program those buttons to do certain actions (hardware macro scripting through a program provided with the mouse). Gameguard is probably blocking it. Try a cheapy mouse, most likely the one that came with your system if a pre-packaged rig, test that out. Also if it is the mouse that came with the system, try to find a cheap PS/2 port mouse if USB mouse or vice versa if a PS/2 mouse try a USB one.
PS/2 will look something like this here...
http://en.wikipedia.org/wiki/PS/2_connector
Also if it is just a basic USB mouse, try plugging it into another USB port on the box proper in front or back where ever you got a spare port, and if plugged into a hub, try direct connection.
hth
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